Investor Presentation 2016

TM

TSX-V: SBM

Forward Looking Statements Sirona Biochem cautions you that statements included in this presentation that are not a description of historical facts may be forward-looking statements. Forward-looking statements are only predictions based upon current expectations and involve known and unknown risks and uncertainties. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of release of the relevant information, unless explicitly stated otherwise. Actual results, performance or achievement could differ materially from those expressed in, or implied by, Sirona Biochem’s forward-looking statements due to the risks and uncertainties inherent in Sirona Biochem’s business including, without limitation, statements about: the progress and timing of its clinical trials; difficulties or delays in development, testing, obtaining regulatory approval, producing and marketing its products; unexpected adverse side effects or inadequate therapeutic efficacy of its products that could delay or prevent product development or commercialization; the scope and validity of patent protection for its products; competition from other pharmaceutical or biotechnology companies; and its ability to obtain additional financing to support its operations. Sirona Biochem does not assume any obligation to update any forward-looking statements except as required by law. TSX-V: SBM

Introduction and History

Sirona Biochem (Parent Company) Vancouver, BC, Canada

TFChem (Wholly Owned Subsidiary) Cosmetic Valley, France

• Sirona Biochem was founded in 2009 • TFChem was acquired in 2011 TSX-V: SBM

Sirona’s Fluorination Chemistry Technology The Solution to Unstable Carbohydrate Molecules

Carbohydrate molecules are unstable by nature Our technology stabilizes carbohydrate molecules

Resulting in improved bioavailability and selectivity that translates into better safety and efficacy

TSX-V: SBM

Investment Highlights • Sirona Biochem has developed a safe and effective skin lightener that is hydroquinone free with 8 times the efficacy of deoxyarbutin • Our discounted cash flow models estimate a NPV of $240 million including upfront, milestone and royalty payments • Our technologies are currently partnered with Valeant/Obagi and Wanbang/Fosun

TSX-V: SBM

Current Collaborations & Pipeline Cosmetic Products Therapeutic Area

Compound

Partnering Status

Skin lightening

TFC-849

Valeant / Obagi

Skin lightening (Rx & OTC)

TFC-1067

In partnering discussions

Cell Preservation

Various

In R&D

Anti-Aging

Various

In R&D

Keloid Scar Treatment

Various

In R&D

Acne Treatment

Various

In R&D

TSX-V: SBM

Current Collaborations & Pipeline Pharmaceutical Products Therapeutic Area

Compound

Partnering Status

Diabetes

TFC-039

Wanbang / Fosun (China) Ready for licensing in ROW

Regenerative Medicine

TFC-1165

In R&D

Inflammatory Disease

TFC-1227

JV with Bloom Burton & Co

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Leading Cosmetic and Pharmaceutical Companies

TSX-V: SBM

Business Development Strategy

• License TFC-1067 to a major industry partner with a commercial and R&D Infrastructure in Japan, Asia-Pacific, Europe and North America

TSX-V: SBM

Global Skin Lightening Market 25.0

$ billions

20.0

17.3

18.1

18.9

19.8

2016 13.2 4.5 0.4

2017 13.7 4.8 0.4

2018 14.1 5.2 0.5

15.0 10.0 5.0 0.0 Japan Asia-Pacific US, EU, ROW

TSX-V: SBM

2015 12.8 4.1 0.4

Revenue Generating Opportunities* Description

2016A

2016E

2017E

2018E

2019E

Material Assumptions / Factors

2020E

Material Risk Factors

• • Upfront payment of $90M in Q3 (**)

Successful licensing of TFC-1067

Milestone payment of $98M (**)

Ongoing royalties totaling $715M (**)

Assumes exclusive worldwide rights. • Peak penetration at year 10 = 15%. • 10 year sales period from 2019 to 2028. (20 year patent protection). ** Please see next slide for comparable transactions.

• • •

• Commercialization of TFC-849 Valeant / Obagi

•

First royalty payment in Q2

Assumes active ingredient is utilized in existing formulations.

• •

• Licensing agreement for TFC-039 ($9.5M + royalties) Wanbang / Fosun

$300K milestone payment received

$500K upon IND filing

$500K Phase I

$1.5M Phase 3 CTA

•

These milestone payments are according to the licensing agreement.

• •

1067 is not licensed to a major corporation. Unfavorable testing results. Change in business priority of potential partner. Merger or acquisition of a potential partner creates unexpected delays.

Chemical processes and scale-up are not economically viable. Delays in commercialization. Unfavorable testing results.

Chemical processes and scale-up are not economically viable. First line tests by Wanbang are not acceptable to them. Change in business priority.

*The sole purpose of the forward looking information is to show the potential revenue generation from milestones achieved for the noted compounds/products if same wereTSX-V: achieved.SBM The potential revenue shown is not a forecast but solely a target for Sirona management.

Comparable Transactions •

Average dermatology royalty rates = 17.7%

•

Medicis Pharmaceuticals acquired the Esoterica skin care product line from SmithKline Beecham Consumer Brands for $9.2 million in 1991 (UK & US territories only).

•

Medicis Pharmaceuticals obtained exclusive worldwide rights for the development and commercialization of an investigational drug targeted at certain topical skin applications in March, 2012. Medicis paid an upfront payment of $25.0 million, an additional $80.0 million upon the achievement of certain research, development and regulatory milestones and up to an additional $120.0 million upon the achievement of certain commercial milestones, as well as royalties on future sales. The total deal value was $225 million.

•

Valeant Pharmaceuticals acquired Medicis Pharmaceuticals in December 2012 for $44.00 per share in cash. The transaction was valued at approximately $2.6 billion.

•

All values mentioned above are in US currency.

TSX-V: SBM

Source: Informa’s Medtrack

Sirona Biochem vs the Nasdaq Biotechnology Index 4,500

0.25

4,000

0.2

3,500

0.15

3,000

0.1

2,500

0.05

2,000

0

TSX-V: SBM

NBI

SBM

Share Capital Shares Issued & O/S: Stock Options:

162,472,548 14,590,000

Warrants - $0.20 strike exp 03/06/2017: 8,865,970 Warrants - $0.30 strike exp 05/11/2018: 2,073,750 Shares Issued (Fully Diluted): 180,002,268 Market Cap: $27,620,333 Cash: $1,200,000

(As at Jun 30/16) TSX-V: SBM

Who we are

Howard J. Verrico, MD CEO and Chairman of the Board

Geraldine Deliencourt-Godefroy, PhD Chief Scientific Officer

Michelle Seltenrich, MBA, BSc VP, Operations

TSX-V: SBM

Christopher Hopton, CGA Chief Financial Officer

Attila Hajdu, MBA, MSc Chief Business Development Officer

Summary

• Sirona Biochem is a discovery and development stage biotechnology company that is the leader in commercializing carbohydrate chemistry • There is an opportunity to license TFC1067 and generate significant revenues in a $20 billion market with a safe and effective product TSX-V: SBM